Acid Bit

By Davis Morris

 Many suppliers include a range of stem cell marker proteins on their antibody databases. Marker antibodies, such as the one selective for Podocalycin-like protein (PODXL) are widely used in research into cancers and other diseases.

The PODXL gene has a similar structure to the CD-34 ligand, and encodes to a member of the sialomucin protein group. Originally identified on epithelial podocyte cells, it has been implicated in the development of aggressive tumours, and is used as a diagnostic marker in numerous cancers, including prostate cancer and pancreatic carcinomas.

At Novus Biologicals, our PODXL TRA-1-81antibody is one of a number of cell surface marker immunoglobulins designed for embryonic stem cell research. It recognises a specific carbohydrate epitope on the PODXL protein, the antigen TRA-1-81. Involved in cell differentiation, TRA-1-81 is expressed through PODXL on the surface of embryonic stem and germ cells, and also upon the surface of adult human teratocarcinoma stem cells. Cell surface antigens are known to play an important role in the ex-pression and function of developmentally controlled cells during embryonic and tumour development. For this reason, embryonic stem cells are routinely used in cancer studies involving TRA-1-81 and other PODXL immunoglobulins.

Since no murine (mouse) immunoreactivity is seen with our TRA PODXL antibodies, human cells must be used. The area of human embryonic stem-cell (hES) research is an extremely controversial one. However, in January 2010 Mizrak, Chikhovskaya et al, of the University of Amsterdam, released a paper suggesting an alternative human adult tissue. Studies had already shown that multipotent ES-type cells could be sourced from adult mouse testes. When these experiments were repeated using tissue donated from prostate cancer patients, subcultured cells expressed hES specific carbohydrate antigens as in the mouse studies. These included TRA-1-60 and TRA-1-81 both of which are on our antibody database.

This study means that human stem cell research is no longer restricted to embryonic cell lines an exciting development in an area which is historically extremely controversial.

The Article is written by novusbio.com/ providing antibody catalogue and antibodies Services. Visit http://www.novusbio.com/ for more information on novusbio.com/Products & Services___________________________Copyright information

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Incredible Science Toys and Kits - Easy to Learn Science

By johnmartin1

 In these technology days,it is one of the easiest tasks for children to learn science quickly.Most of the children would like to do their science experiments with some incredible science toys and kits.Science is one of the easiest subjects to learn with these science kits.And here one thing to remember that science is different from scientific.Obviously,the science experiments involve with great project group discussion,which often lead to toy science fun.There are so many stores situated at the country are selling these incredible science experiment kits,which are made by some esteemed manufacturers are presented in an easy way.And also with the design of these kits,your children will learn some incredible facts about the different scientific disciplines.For example,with a single experiment with these kits,so many children would be able to understand the atmosphere conditions around our planet.

After the completing the experiment,your children will amaze about these kits.And also it will help them to learn science quickly,and also it is very much useful in their future research and education.There are various types of kits available like chemistry,biology,ecology,astronomy and some other various fields of experiment kits.It has been observed in various American schools that so many children are easy to learn that why sky is the blue,cause of rains,bending lights and some other experiments that also reveals the mysteries of earth.Instead of giving some old regular toy,you can give these experimental kits to your beloved children as a gift.When they are doing experiments with these kits,they are using their imagination,as well as they have some interest to learn real science that will help them both in the school and real world.If they are really understandable with these experiments,they are starting to think differently. During these experiments, they are asking some questions and reasons. At the time,as teacher or parent, you need to be patient about give some proper answer to your children.And also there is an important point that parents are the first teacher for any children.Instead of saying the short answer to the children questions, you need to give some elaborated answers.With these answers,they are able to keep this information as a memory,and they know the importance of the science.In earlier stage of learning will help them to be easier in school, and as they grow older.And also is the absolute best way for kids to learn science.

Rather than studying in books,the children will learn the skills faster and save more pleasure when they are having experience.And finally,there are some well established and well experienced manufacturers of this incredible science experiment kit are selling through online.For more information and details,please visit their web site.

Find the best science toys science experiments,science projects, educational toys, science fair projects, cool experiments, fun educational toys, cool science toys, Incredible science projects and cool science fair projects at this web site.

science and technology

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